Analysis of Pharmacokinetic Data

Ha Nguyen and Dhammika Amaratunga
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Ha Nguyen: Merck Research Laboratories
Dhammika Amaratunga: The R. W. Johnson Pharmaceutical Research Institute

Chapter 5 in Applied Statistics in the Pharmaceutical Industry, 2001, pp 109-133 from Springer

Abstract: Abstract Pharmacokinetics is the study of the time course of a drug administered to a biological organism, in particular, a human. A drug, following administration, is processed by the body in a series of stages: absorption, distribution, metabolism and elimination; these stages are often abbreviated by their initials, ADME. Since the nature, intensity, and duration of a drug’s biologic effects depend on the amount of drug available to the body and, more specifically, to the amount of drug available at the target site in the body, pharmacokinetic studies play an integral role in a drug’s development.

Keywords: Bayesian Information Criterion; Data Frame; Median Absolute Deviation; Nonlinear Mixed Effect Model; Terminal Elimination Phase (search for similar items in EconPapers)
Date: 2001
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DOI: 10.1007/978-1-4757-3466-9_5

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