Stochastic Modeling of Cargo Transport by Teams of Molecular Motors

Sarah Klein (), Cécile Appert-Rolland and Ludger Santen
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Sarah Klein: Universität des Saarlandes, Theoretical Physics
Cécile Appert-Rolland: University Paris-Sud, Laboratory of Theoretical Physics, Batiment 210
Ludger Santen: Universität des Saarlandes, Theoretical Physics

A chapter in Traffic and Granular Flow '13, 2015, pp 609-617 from Springer

Abstract: Abstract Many different types of cellular cargos are transported bidirectionally along microtubules by teams of molecular motors. The motion of this cargo-motors system has been experimentally characterized in vivo as processive with rather persistent directionality. Different theoretical approaches have been suggested in order to explore the origin of this kind of motion. An effective theoretical approach, introduced by Müller et al. [9], describes the cargo dynamics as a tug-of-war between different kinds of motors. An alternative approach has been suggested recently by Kunwar et al. [7], who considered the coupling between motor and cargo in more detail.Based on this framework we introduce a model considering single motor positions which we propagate in continuous time. Furthermore, we analyze the possible influence of the discrete time update schemes used in previous publications on the system’s dynamic.

Keywords: Effective Theoretical Approach; Kunwar; Parallel Update Scheme; Preferred Walking Direction; General Movement Conditions (search for similar items in EconPapers)
Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-3-319-10629-8_69

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DOI: 10.1007/978-3-319-10629-8_69

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