The VasCan Project: Simulation of Vascular Tumour Growth and Angiogenesis Using a Multiscale Model

Bernd-Simon Dengel, Holger Perfahl, Simona Galliani and Matthias Reuss
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Bernd-Simon Dengel: University of Stuttgart, Stuttgart Research Center Systems Biology (SRCSB)
Holger Perfahl: University of Stuttgart, Stuttgart Research Center Systems Biology (SRCSB)
Simona Galliani: University of Stuttgart, Stuttgart Research Center Systems Biology (SRCSB)
Matthias Reuss: University of Stuttgart, Stuttgart Research Center Systems Biology (SRCSB)

A chapter in High Performance Computing in Science and Engineering ‘14, 2015, pp 683-691 from Springer

Abstract: Abstract In the VasCan project we use a multiscale model [1, 2] to simulate angiogenesis and vascular tumour growth. The model is based on a cellular automaton approach and couples intracellular processes, active cell movement, cell-cell interaction, extracellular diffusion, and a dynamically evolving vascular network. In order to obtain a better understanding of both our model parameters and the interaction between the model modules, we conducted a sensitivity analysis. The simulation studies are controlled via a MatLab/Java programme that generates parameter files, starts the simulations on the HLRS and finally organises the transfer and storage of the simulation results. The visualisation of the large data sets was also automated. The goal is to improve our model understanding and the predictive potential for future tumour growth and therapy simulations.

Keywords: Cellular Automaton; Multiscale Model; Independent Simulation; Parameter File; Partial Differential Equation Model (search for similar items in EconPapers)
Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-3-319-10810-0_45

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DOI: 10.1007/978-3-319-10810-0_45

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