Translational Clinical Trials

Steven Piantadosi ()
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Steven Piantadosi: Brigham and Women’s Hospital, Harvard Medical School, Department of Surgery, Division of Surgical Oncology

Chapter 52 in Principles and Practice of Clinical Trials, 2022, pp 939-950 from Springer

Abstract: Abstract Translational research and clinical trials are often discussed especially in academic centers from the perspective that such efforts are difficult or endangered. Yet every new therapeutic must pass through this stage of investigation where promising evidence supports staged development with the goal of product registration. Many clinical investigators instinctively know that relatively small clinical trials can be essential in translation, but this is often contrary to the statistical rigors of later development. This chapter attempts to reconcile these equally valid perspectives.

Keywords: Translational research; Translational clinical trials; Biomarkers; Information; Entropy; Sample size (search for similar items in EconPapers)
Date: 2022
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DOI: 10.1007/978-3-319-52636-2_76

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