Adjusting for Imbalance in Pre-Vaccination State

Jozef Nauta ()
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Jozef Nauta: Global Statistics, Solvay Pharmaceuticals

Chapter Chapter 5 in Statistics in Clinical Vaccine Trials, 2011, pp 57-65 from Springer

Abstract: Abstract For some infectious diseases, pre-vaccination antibody levels are not zero. Not all vaccines offer life-long protection, and a number of diseases require re-vaccinations throughout life. Antibody levels prior to re-vaccination with, for example, a tetanus, a diphtheria, a pertussis or a tick borne encephalitis vaccine will often not be zero. If pre-vaccination (baseline) antibody levels are not zero, then the post-vaccination values do not only express the immune responses to the vaccination, but also the subjects’ pre-vaccination state. This can complicate the interpretation of a difference in post-vaccination antibody values between vaccine groups. If there is imbalance in pre-vaccination state, i.e., if there is a difference in baseline antibody values between groups, then part of the post-vaccination difference can be explained by the pre-vaccination difference.

Keywords: Vaccine Group; Baseline Imbalance; Control Vaccine; Clinical Vaccine Trial; Seronegative Subject (search for similar items in EconPapers)
Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-3-642-14691-6_5

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DOI: 10.1007/978-3-642-14691-6_5

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