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Numerical Simulation of Annular Chromatography

Lutz Tobiska () and Angela Thiele
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Lutz Tobiska: Otto-von-Guericke-Universität Magdeburg, Institut für Analysis und Numerik
Angela Thiele: Otto-von-Guericke-Universität Magdeburg, Institut für Analysis und Numerik

A chapter in Mathematics — Key Technology for the Future, 2003, pp 194-203 from Springer

Abstract: Abstract This project is carried out jointly with Prof. Seidel-Morgenstern from the Institute for Process Engineering of university of Magdeburg and with the support of Schering AG at Berlin. Preparative chromatography attains increasing importance for the isolation and purification of value added products in the pharmaceutical industry and in biotechnology. The goal of this project is the numerical simulation of the separation process in an annular Chromatograph to study the influence of the main design parameters on the efficiency of the multicomponent separation. Simulations to optimize the separation process with the aim of a high efficiency of pure products are of special interests. On the basis of the mass balance equations a mathematical model is proposed and an efficient solution strategy is developed using streamline diffusion method, adaptive refinement and multigrid solver.

Keywords: Separation Process; Outflow Boundary; Pure Fraction; Adaptive Mesh Refinement; Multigrid Solver (search for similar items in EconPapers)
Date: 2003
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Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-3-642-55753-8_16

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DOI: 10.1007/978-3-642-55753-8_16

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