Quality-of-Life Assessments in Clinical Trials

Ton J. Cleophas, Aeilko H. Zwinderman and Toine F. Cleophas
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Ton J. Cleophas: European Interuniversity College of Pharmaceutical Medicine Lyon
Aeilko H. Zwinderman: European Interuniversity College of Pharmaceutical Medicine Lyon
Toine F. Cleophas: Technical University

Chapter Chapter 15 in Statistics Applied to Clinical Trials, 2002, pp 157-166 from Springer

Abstract: Summary Background: Two major issues in quality of life (QOL) research include the patients’ opinion as a contributing factor in QOL-assessments, and the lack of sensitivity of QOL-assessments. Objectives: To review results from recent research by the Dutch Mononitrate Quality Of Life (DUMQOL) Study Group relevant to these issues. Results: Using a test-battery including Stewart’s Short Form (SF)-36 Questionnaire and the DUMQOL-50 questionnaire, the DUMQOL Study Group tested the hypothesis that the patients’ opinion might be an independent determinant of QOL and performed for that purpose a stepwise multiple regression analysis of data from 82 outpatient clinic patients with stable angina pectoris. Psychological distress was the most important contributor to QOL (beta 0.43, P

Keywords: Angina Pectoris; Domain Score; Stepwise Multiple Regression Analysis; Anginal Pain; Mobility Difficulty (search for similar items in EconPapers)
Date: 2002
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DOI: 10.1007/978-94-010-0337-7_15

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