Association of IL-6 Gene rs1800796 Polymorphism with Cancer Risk: A Meta-Analysis

Md. Harun-Or-Roshid (), Md. Borqat Ali (), Jesmin () and Md. Nurul Haque Mollah ()
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Md. Harun-Or-Roshid: University of Rajshahi, Department of Statistics
Md. Borqat Ali: University of Rajshahi, Department of Statistics
Jesmin: University of Dhaka, Department of Genetic Engineering and Biotechnology
Md. Nurul Haque Mollah: University of Rajshahi, Department of Statistics

A chapter in Data Science and SDGs, 2021, pp 31-43 from Springer

Abstract: Abstract Interleukin-6 (IL-6) gene polymorphisms are a crucial functional marker in human body. Several genetic association studies reported the significant association between IL-6 gene and various major disease and cancers. In this study, the association of IL-6 gene polymorphism (rs1800796) with cancer risk was investigated through a meta-analysis, which included the larger sample size. To find the association between IL-6 gene (−572 G/C) polymorphism, we extracted the dataset in 27 eligible studies for 24,138 subjects through an efficient searching strategy from PubMed, PubMed central, web of science, google scholar, and other relevant biological literature-based online databases until February 2019. We investigated the association by comparing the allelic and genotypic case–control frequency based on odds ratio with 95% confidence interval and some other statistical tests. According to the results, the rs1800796 SNP significantly associated with increasing risk (CG vs. CC + GG: OR = 1.12, 95% CI = 1.01 – 1.23, p = 0.0288) of overall cancer, particularly with lung, stomach, and prostate cancer as well as for Asian ethnicity. These findings suggest that IL-6 gene polymorphisms may appraise as a genetic biomarker for cancer risks.

Keywords: Association; Interleukin-6 gene; Cancer risk; Case–Control studies; Sample size; Meta-analysis (search for similar items in EconPapers)
Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-981-16-1919-9_3

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DOI: 10.1007/978-981-16-1919-9_3

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