Introduction to Basket Trials

Haitao Pan () and Ying Yuan ()
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Haitao Pan: St. Jude Children’s Research Hospital, Department of Biostatistics
Ying Yuan: The University of Texas MD Anderson Cancer Center, Department of Biostatistics

Chapter Chapter 8 in Bayesian Adaptive Design for Immunotherapy and Targeted Therapy, 2023, pp 149-200 from Springer

Abstract: Abstract With the advent of targeted therapies and immunotherapies, precision medicine has entered clinical practice. Basket trials provide an important approach to evaluating treatment effects of targeted therapies and immunotherapies. Under the basket trial, patients with the same genetic or molecular aberrations, regardless of their cancer types, are enrolled in the trial for evaluating the effect of a targeted agent. The basket trial allows for the incorporation of precision medicine into clinical trials. This chapter introduces several frequentist and Bayesian designs for basket trials, with a special focus on borrowing information across cancer types using Bayesian hierarchical model approaches. Software for some designs are described.

Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-981-19-8176-0_8

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DOI: 10.1007/978-981-19-8176-0_8

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