First comprehensive untargeted metabolomics study of suramin-treated Trypanosoma brucei: an integrated data analysis workflow from multifactor data modelling to functional analysis

Fanta Fall, Lucia Mamede, Madeline Vast, Pascal De Tullio, Hayette, Marie‑Pierre, Bernadette Govaerts and E.A.,
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Fanta Fall: Université catholique de Louvain
Lucia Mamede: Université de Liège
Madeline Vast: Université catholique de Louvain, LIDAM/ISBA, Belgium
Pascal De Tullio: Université de Liège
Hayette, Marie‑Pierre: Université de Liège
Bernadette Govaerts: Université catholique de Louvain, LIDAM/ISBA, Belgium

No 2024007, LIDAM Reprints ISBA from Université catholique de Louvain, Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA)

Abstract: Through the integration of LC–MS and NMR techniques coupled with advanced statistical analyses, this study identifies distinctive metabolic signatures and pathways associated with suramin treatment in T. brucei. These findings contribute to a deeper understanding of the pharmacological impact of suramin and have the potential to inform the development of more efficacious therapeutic strategies against African trypanosomiasis.

Keywords: Metabolomics; Suramin; Trypanosoma brucei; Mass spectrometry; Nuclear magnetic resonance (search for similar items in EconPapers)
Pages: 17
Date: 2024-02-23
Note: In: Metabolomics, 2024, vol. 20, 25
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Persistent link: https://EconPapers.repec.org/RePEc:aiz:louvar:2024007

DOI: 10.1007/s11306-024-02094-2

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