Optimal Designs for Discriminating Between some Extensions of the Michaelis-Menten Model

Jesus Lopez Fidalgo, Chiara Tommasi and Camelia Trandafir
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Jesus Lopez Fidalgo: University of Salamanca
Chiara Tommasi: University of Milano
Camelia Trandafir: University of Salamanca

No unimi-1003, UNIMI - Research Papers in Economics, Business, and Statistics from Universitá degli Studi di Milano

Abstract: In this paper some results on the problem of computing optimal designs for discriminating between rival models are provided. Using T-optimality for two rival models a compound criterion is developed to discriminate between more than two models. Surprising results arise when T-optimal designs are compared with classical c-optimal designs for nonlinear models. In particular, some practical deviations of the Michaelis-Menten model are considered in order to measure and compare efficiencies of different designs.

Keywords: Optimal design; compound designs; pharmacokinetic models; T-optimality (search for similar items in EconPapers)
Date: 2005-04-29
Note: oai:cdlib1:unimi-1003
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