Multivariate mixed models for metanalysis of paired-comparison studies of two medical diagnostic tests

Ben Dwamena

Summer North American Stata Users' Group Meetings 2008 from Stata Users Group

Abstract: We have previously demonstrated Stata implementation of bivariate ramdom effects meta-analysis of the sensitivity and specificity of a single binary diagnostic test by means of the midas module (Dwamena NASUG2007; Dwamena WCSUG 2007). In this presentation we extend our work to paired-comparison studies of two binary diagnostic tests. Using a dataset of studies comparing the accuracy of positron emission tomography(PET) and x-ray computed tomography (CT) for staging lung cancer, we compare the fit(deviance) and complexity (BIC, AIC) and test performance estimates (sensitivity, specificity, dignostic odds ratios nand likelihood ratios) of 4 multivariate models : (1) bivariate binomial mixed model with test type as fixed-effect covariate; (2) bivariate binomial mixed model with test type as random-effect covariate; (3) independent test-specific bivariate binomial mixed models; and (4) correlated test-specific bivariate binomial mixed models. Estimation is performed with the Stata-native procedure xtmelogit using both the default adaptive quadrature method and its laplacian approximation (nip=1). Results are then compared with those from the user-written gllamm command (Rabe-Hesketh et al.)

Date: 2008-07-29
New Economics Papers: this item is included in nep-dcm
References: Add references at CitEc
Citations:

Downloads: (external link)
http://repec.org/snasug08/dwamena_snasug2008.pdf (application/pdf)
http://repec.org/snasug08/dwamena_snasug2008.do (text/plain)
http://repec.org/snasug08/dwamena_snasug2008.dta (application/x-stata)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:boc:nsug08:11

Access Statistics for this paper

More papers in Summer North American Stata Users' Group Meetings 2008 from Stata Users Group Contact information at EDIRC.
Bibliographic data for series maintained by Christopher F Baum ().