Statistical Analysis of the Additive and Multiplicative Hypotheses of Multiple Exposure Synergy For Cohort and Case-Control Studies

Jeffrey A. Dubin

No 1066, Working Papers from California Institute of Technology, Division of the Humanities and Social Sciences

Abstract: This paper considers hypotheses tests for synergistic relationships in epidemiological studies. Two hypotheses are considered. First, I develop tests of the additive hypothesis which states that the combined risk from two sources of exposure is the sum of each risk taken separately. I then develop tests for the hypothesis that a multiplicative relationship exists for the risks, i.e., that the combined risk is consistent with the multiplication of the individual risks. Following standard practice in epidemiological studies I consider tests for both case-referent and cohort (standardized mortality rate) type studies.

Keywords: synergy; cohort; case-control; epidemiology (search for similar items in EconPapers)
Pages: 32 pages
Date: 1999-07
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