A case-only approach for assessing gene-sex interaction in human longevity

Qihua Tan, Anatoli I. Yashin, Else M. Bladbjerg, Moniek De Maat, Karen Andersen-Ranberg, Bernard Jeune, Kaare Christensen and James W. Vaupel
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Qihua Tan: Max Planck Institute for Demographic Research, Rostock, Germany
Anatoli I. Yashin: Max Planck Institute for Demographic Research, Rostock, Germany
James W. Vaupel: Max Planck Institute for Demographic Research, Rostock, Germany

No WP-2001-012, MPIDR Working Papers from Max Planck Institute for Demographic Research, Rostock, Germany

Abstract: As one aspect of the complex feature of longevity, gene-sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing gene-sex interaction are expected. New and valid statistical methods are needed. In this paper, we introduce a nontraditional approach, the case-only design, which was originally proposed for assessing gene and disease associations, to detect gene-sex interaction in human longevity. Applications of this method to data collected from centenarian studies show that it can produce consistent results as compared with results obtained from case-control and other approaches. Important features of the application in human longevity studies are highlighted and discussed. Since centenarians constitute a special population representing successful ageing, the easily applicable case-only approach will be an important tool for screening potential major genes that contribute to human longevity. (AUTHORS)

JEL-codes: J1 Z0 (search for similar items in EconPapers)
Date: 2001
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Persistent link: https://EconPapers.repec.org/RePEc:dem:wpaper:wp-2001-012

DOI: 10.4054/MPIDR-WP-2001-012

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