ADDIS

Gert van Valkenhoef, E.O. de Brock, Hans Hillege and Jing Zhao
Additional contact information
Jing Zhao: Groningen University

No 12007-Other, Research Report from University of Groningen, Research Institute SOM (Systems, Organisations and Management)

Abstract: In evidence-based medicine, meta-analysis is an important statistical technique for combining the findings from independent clinical trials which have attempted to answer similar questions about treatment's clinical eectiveness [1]. Normally, such meta-analyses are pair-wise treatment comparisons, which only include the comparisons between two treatments, e.g. treatment A and placebo. When additional treatments are of interest (e.g. treatment B and treatment C), pair-wise treatment comparison starts showing its limitations as it only accesses the evidence from direct comparisons between two treatments and can not guarantee consistency between comparisons. Network meta-analysis is a statistical method for combining both direct and indirect evidence from multiple trials in order to obtain a single consistent quantitative synthesis [2, 3, 4]. It enables to detect the heterogeneity among dierent trials comparing the same treatments and inconsistency between direct and indirect evidence. Compared to pair-wise meta-analysis, network meta-analysis is rather difficult to conduct due to the need for analyzing inconsistency, specifying the model, assessing convergence, etc. The purpose of this report is to introduce an automated way to perform network meta-analysis through ADDIS (Aggregate Data Drug Information System).

Date: 2012
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
http://hdl.handle.net/11370/07a5f617-ce8d-455a-8a1d-050eea209dcc (application/pdf)
Our link check indicates that this URL is bad, the error code is: 403 Forbidden (http://hdl.handle.net/11370/07a5f617-ce8d-455a-8a1d-050eea209dcc [302 Found]--> https://research.rug.nl/en/publications/07a5f617-ce8d-455a-8a1d-050eea209dcc [301 Moved Permanently]--> https://research.rug.nl/en/publications/addis-an-automated-way-to-do-network-meta-analysis)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gro:rugsom:12007-other

Access Statistics for this paper

More papers in Research Report from University of Groningen, Research Institute SOM (Systems, Organisations and Management) Contact information at EDIRC.
Bibliographic data for series maintained by Hanneke Tamling ().