The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study

Bénédicte Stengel, Christian Combe, Christian Jacquelinet, Serge Briançon, Denis Fouque (), Luc Frimat (), Christophe Pascal (), Yves-Edouard Herpe (), Jean-François Deleuze (), Joost Schanstra (), Ron L. Pisoni, Bruce M Robinson and Ziad A Massy ()
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Bénédicte Stengel: CESP - Centre de recherche en épidémiologie et santé des populations - UVSQ - Université de Versailles Saint-Quentin-en-Yvelines - UP11 - Université Paris-Sud - Paris 11 - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Paul Brousse - INSERM - Institut National de la Santé et de la Recherche Médicale
Christian Combe: Fibrose hépatique et cancer du foie - Université Bordeaux Segalen - Bordeaux 2 - IFR66 - INSERM - Institut National de la Santé et de la Recherche Médicale, Service de Néphrologie-transplantation-dialyse [Bordeaux] - CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
Christian Jacquelinet: Agence de la biomédecine [Saint-Denis la Plaine]
Serge Briançon: APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation - UPD5 - Université Paris Descartes - Paris 5 - UL - Université de Lorraine, CIC-EC - Centre d'investigation clinique - Epidémiologie clinique [Nancy] - CIC - Centre d'investigation clinique [Nancy] - CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy - INSERM - Institut National de la Santé et de la Recherche Médicale - UL - Université de Lorraine
Denis Fouque: CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition - INRA - Institut National de la Recherche Agronomique - UCBL - Université Claude Bernard Lyon 1 - Université de Lyon - INSA Lyon - Institut National des Sciences Appliquées de Lyon - Université de Lyon - INSA - Institut National des Sciences Appliquées - HCL - Hospices Civils de Lyon - INSERM - Institut National de la Santé et de la Recherche Médicale, CHLS - Centre Hospitalier Lyon Sud [CHU - HCL] - HCL - Hospices Civils de Lyon
Luc Frimat: CIC-EC - Centre d'investigation clinique - Epidémiologie clinique [Nancy] - CIC - Centre d'investigation clinique [Nancy] - CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy - INSERM - Institut National de la Santé et de la Recherche Médicale - UL - Université de Lorraine, Service de Néphrologie [CHRU Nancy] - CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
Christophe Pascal: CRDMS - GRAPHOS - IFROSS Recherche - UJML - Université Jean Moulin - Lyon 3 - Université de Lyon
Yves-Edouard Herpe: Transfert de gènes dans le foie : applications thérapeutiques - UP11 - Université Paris-Sud - Paris 11 - IFR93 - INSERM - Institut National de la Santé et de la Recherche Médicale, CHU Amiens-Picardie
Jean-François Deleuze: CNG - Centre National de Génotypage - CEA - Commissariat à l'énergie atomique et aux énergies alternatives
Joost Schanstra: I2MC - Institut des Maladies Métaboliques et Cardiovasculaires - UT3 - Université Toulouse III - Paul Sabatier - UT - Université de Toulouse - INSERM - Institut National de la Santé et de la Recherche Médicale
Ron L. Pisoni: Arbor Research Collaborative for Health
Bruce M Robinson: Arbor Research Collaborative for Health
Ziad A Massy: CHU Amiens-Picardie, Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux - UPJV - Université de Picardie Jules Verne - INSERM - Institut National de la Santé et de la Recherche Médicale, CESP - Centre de recherche en épidémiologie et santé des populations - UVSQ - Université de Versailles Saint-Quentin-en-Yvelines - UP11 - Université Paris-Sud - Paris 11 - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Paul Brousse - INSERM - Institut National de la Santé et de la Recherche Médicale

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Abstract: Background While much has been learned about the epidemiology and treatment of end-stage renal disease (ESRD) in the last 30 years, chronic kidney disease (CKD) before the end-stage has been less investigated. Not enough is known about factors associated with CKD progression and complications, as well as its transition to ESRD. We designed the CKD-renal epidemiology and information network (REIN) cohort to provide a research platform to address these key questions and to assess clinical practices and costs in patients with moderate or advanced CKD. Methods A total of 46 clinic sites and 4 renal care networks participate in the cohort. A stratified selection of clinic sites yields a sample that represents a diversity of settings, e.g. geographic region, and public versus for-profit and non-for-profit private clinics. In each site, 60-90 patients with CKD are enrolled at a routine clinic visit during a 12-month enrolment phase: 3600 total, including 1800 with Stage 3 and 1800 with Stage 4 CKD. Follow-up will continue for 5 years, including after initiation of renal replacement therapy. Data will be collected from medical records at inclusion and at yearly intervals, as well as from self-administered patient questionnaires and provider-level questionnaires. Patients will also be interviewed at baseline, and at 1, 3 and 5 years. Healthcare costs will also be determined. Blood and urine samples will be collected and stored for future studies on all patients at enrolment and at study end, and at 1 and 3 years in a subsample of 1200. Conclusions The CKD-REIN cohort will serve to improve our understanding of the biological, clinical and healthcare system determinants associated with CKD progression and adverse outcomes as well as of international variations in collaboration with the CKD Outcome and Practice Pattern Study (CKDopps). It will foster CKD epidemiology and outcomes research and provide evidence to improve the health and quality of life of patients with CKD and the performances of the healthcare system in this field.

Keywords: biomarkers; chronic kidney disease; clinical practice; cohort; quality of life (search for similar items in EconPapers)
Date: 2014-07-22
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Published in Nephrology Dialysis Transplantation, 2014, 29 (8), pp.1500 - 1507. ⟨10.1093/ndt/gft388⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-00932387

DOI: 10.1093/ndt/gft388

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