Validation of the psychometrics properties of a French quality of life ă questionnaire among a cohort of renal transplant recipients less than ă one year

Davy Beauger, Dorothée Fruit, Claire Villeneuve, Marie-Laure Laroche, Elisabeth Jouve, Annick Rousseau, Laurent Boyer () and Stéphanie Gentile
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Dorothée Fruit: PIST - Pharmacologie des Immunosuppresseurs et de la Transplantation - UNILIM - Université de Limoges - CHU Limoges - GEIST FR CNRS 3503 - Génomique, Environnement, Immunité, Santé, Thérapeutique - INSERM - Institut National de la Santé et de la Recherche Médicale
Claire Villeneuve: PIST - Pharmacologie des Immunosuppresseurs et de la Transplantation - UNILIM - Université de Limoges - CHU Limoges - GEIST FR CNRS 3503 - Génomique, Environnement, Immunité, Santé, Thérapeutique - INSERM - Institut National de la Santé et de la Recherche Médicale
Marie-Laure Laroche: HAVAE - Handicap, Activité, Vieillissement, Autonomie, Environnement - GEIST - Institut Génomique, Environnement, Immunité, Santé, Thérapeutique - UNILIM - Université de Limoges, Service de Pharmacologie, toxicologie et pharmacovigilance [CHU Limoges] - CHU Limoges
Elisabeth Jouve: CIC - Centre d'Investigation Clinique [Hôpital de la Conception - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - IPC - Institut Paoli-Calmettes - Fédération nationale des Centres de lutte contre le Cancer (FNCLCC) - INSERM - Institut National de la Santé et de la Recherche Médicale - LA CONCEPTION - Hôpital de la Conception [CHU - APHM], TIMONE - Hôpital de la Timone [CHU - APHM]
Annick Rousseau: CHU Saint-Antoine [AP-HP] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - SU - Sorbonne Université
Laurent Boyer: C3M - Centre méditerranéen de médecine moléculaire - UNS - Université Nice Sophia Antipolis (1965 - 2019) - INSERM - Institut National de la Santé et de la Recherche Médicale - UniCA - Université Côte d'Azur
Stéphanie Gentile: ASL Salerno

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Abstract: Background Renal transplantation is considered as the treatment of ă choice for patients with end-stage renal disease. Health-related quality ă of life (HRQoL) of renal transplant recipients (RTR) is very important ă to assess, especially during the first year after transplantation. To ă provide new evidence about the suitability of HRQoL measures in RTR ă during the first post-transplant year, we explored the internal ă structure, reliability and external validity of a French specific HRQoL ă instrument, the Renal Transplant Quality of life Questionnaire Second ă Version (RTQ V2). ă Methods The data were issued from the French multicenter cohort of renal ă transplant patients followed during 4 years (EPIGREN). The HRQoL of RTR ă was assessed five times (at 1, 3, 6, 9 and 12 months after ă transplantation) with the RTQ V2, a specific instrument consisting of 32 ă items describing five dimensions. Socio-demographic information, ă clinical characteristics and HRQoL (i.e., RTQ V2 and SF-36) were ă collected. For the five times, psychometric properties of the RTQ V2 ă were compared to those reported from the reference population assessed ă in the validation study. ă Results Three hundred and thirty-four patients were enrolled. The ă proportions of well-projected items, item-internal consistency, ă item-discriminant validity, floor and ceiling effects, Cronbach's alpha ă coefficients and item goodness-of-fit statistics were satisfactory for ă each dimension at the five times of the study. The suitability indices ă of construct validity were higher than 90 % for each time ă (minimum-maximum: 90.8-97.4 %). The external validity was less ă satisfactory, with a suitability indices ranged from 46.7 % at M1 to ă 66.7 % at M12. However, the discrepancies with the reference population ă (mainly for the gender) appeared logical considering the scientific ă literature on HRQoL of RTR during the first post-transplant year and may ă not compromise the external validity. ă Conclusion These results support the validity and reliability of the RTQ ă V2 for evaluating HRQoL in RTR during the first post-transplant year, ă and confirm that the RTQ V2 is a useful tool to assess the HRQoL ă precociously after transplant.

Keywords: quality (search for similar items in EconPapers)
Date: 2016-09
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Published in Quality of Life Research, 2016, 25 (9), pp.2347-2359. ⟨10.1007/s11136-016-1271-0⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482346

DOI: 10.1007/s11136-016-1271-0

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