A structural equation modelling approach to explore the determinants of ă quality of life in schizophrenia

Marine Alessandrini, Christophe Lançon (), Guillaume Fond (), Catherine Faget-Agius, Raphaëlle Richieri, Mélanie Faugere, Emeline Metairie, Mohamed Boucekine, Pierre-Michel Llorca (), Pascal Auquier () and Laurent Boyer ()
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Marine Alessandrini: SPMC - Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille
Christophe Lançon: Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM]
Guillaume Fond: INSERM U955, équipe 15 - Service de psychiatrie - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Henri Mondor - Hôpital Albert Chenevier - Réseau de coopération scientifique en santé mentale - Fondation FondaMental [Créteil] - IMRB - Institut Mondor de Recherche Biomédicale - INSERM - Institut National de la Santé et de la Recherche Médicale - UPEC UP12 - Université Paris-Est Créteil Val-de-Marne - Paris 12
Raphaëlle Richieri: Laboratoire de santé publique évaluation des systèmes de soins et santé perçue, Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM]
Mélanie Faugere: LNC - Laboratoire de Neurosciences Cognitives [Marseille] - AMU - Aix Marseille Université - CNRS - Centre National de la Recherche Scientifique, Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM], Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM]
Mohamed Boucekine: SPMC - Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille
Pierre-Michel Llorca: Service Psychiatrie Adulte [CHU Clermont-Ferrand] - CHU Gabriel Montpied [Clermont-Ferrand] - CHU Clermont-Ferrand - Pôle Psychiatrie Enfant-Adulte [CHU Clermont-Ferrand] - CHU Clermont-Ferrand - CHU Gabriel Montpied [Clermont-Ferrand] - CHU Clermont-Ferrand
Pascal Auquier: SPMC - Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille
Laurent Boyer: C3M - Centre méditerranéen de médecine moléculaire - UNS - Université Nice Sophia Antipolis (1965 - 2019) - INSERM - Institut National de la Santé et de la Recherche Médicale - UniCA - Université Côte d'Azur

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Abstract: Objective: This study aimed to analyse the relationships among psychotic ă symptoms, depression, neurocognition and functioning as determinants of ă quality of life (QoL) in patients with schizophrenia. ă Methods: In this cross-sectional study, we evaluated QoL with the ă Schizophrenia Quality of Life 18-item scale (S-QoL 18), neurocognition ă with multiple tests exploring memory, attention and executive functions, ă the severity of psychotic symptoms with the Positive and Negative ă Syndrome Scale (PANSS), depression with the Calgary Depression Scale for ă Schizophrenia (CDSS) and functioning using the Functional Remission Of ă General Schizophrenia (FROGS) scale. We used Structural Equation ă Modelling (SEM) to describe the relationships among the severity of ă psychotic symptoms, depression, neurocognition, functioning and QoL. ă Results: Two hundred and seventy-one outpatients with schizophrenia ă participated in our study. SEM showed good fit with chi(2)/df = 1.97, ă root mean square error of approximation = 0.06, comparative fit index = ă 0.93 and standardized root mean square residuals = 0.05. This model ă revealed that depression was the most important feature associated with ă QoL, mainly for the self-esteem, autonomy and resilience dimensions ă (direct path coefficient = -0.46). The direct path between functioning ă and QoL was also significant (path coefficient = 0.26). The severity of ă psychotic symptoms and neurocognitive impairment were weakly and ă indirectly associated with QoL via functioning (path coefficients = ă -0.18 and 0.04, respectively). ă Conclusions: This study contributes to a better understanding of the ă determinants of QoL in schizophrenia. Our findings should be considered ă in developing effective strategies for improving QoL among this ă population. (C) 2016 Elsevier B.V. All rights reserved.

Keywords: Quality (search for similar items in EconPapers)
Date: 2016-03
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Published in Schizophrenia Research, 2016, 171 (1-3), pp.27-34. ⟨10.1016/j.schres.2016.01.012⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482502

DOI: 10.1016/j.schres.2016.01.012

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