Psychosocial functioning, quality of life and clinical correlates of ă comorbid alcohol and drug dependence syndromes in people with ă schizophrenia across Europe

Giuseppe Carra, Sonia Johnson, Cristina Crocamo, Matthias C. Angermeyer, Traolach Brugha, Jean-Michel Azorin, Mondher Toumi and Paul E. Bebbington
Additional contact information
Matthias C. Angermeyer: Leipzig University / Universität Leipzig
Traolach Brugha: Leicester NIHR Biomedical Research Unit in Cardiovascular Disease - University of Leicester
Jean-Michel Azorin: Fondation FondaMental [Créteil], Pôle de Psychiatrie - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM] - CHU Marseille
Mondher Toumi: Pharmaco-Epidémiologie - Université Bordeaux Segalen - Bordeaux 2 - INSERM - Institut National de la Santé et de la Recherche Médicale

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Abstract: Little is known about the correlates of comorbid drug and alcohol ă dependence in people with schizophrenia outside the USA. We tested ă hypotheses that dependence on alcohol/drugs would be associated with ă more severe symptoms, and poorer psychosocial functioning and quality of ă life. The EuroSC Cohort study (N=1204), based in France, Germany and the ă UK, used semi-structured clinical interviews for diagnoses, and ă standardized tools to assess correlates. We used mixed models to compare ă outcomes between past-year comorbid dependence on alcohol/drugs, ă controlling for covariates and modelling both subject and country-level ă effects. Participants dependent on alcohol or drugs had fewer negative ă symptoms on PANSS than their non-dependent counterparts. However, those ă dependent on alcohol scored higher on PANSS general psychopathology than ă those who were not, or dependent only on drugs. People with ă schizophrenia dependent on drugs had poorer quality of life, more ă extrapyramidal side effects, and scored worse on Global Assessment of ă Functioning (GAF) than those without dependence. People with alcohol ă dependence reported more reasons for non-compliance with medication, and ă poorer functioning on GAF, though not on Global Assessment of Relational ă Functioning. In people with schizophrenia, comorbid dependence on ă alcohol or drugs is associated with impaired clinical and psycho social ă adjustment, and poorer quality of life. (C) 2016 Elsevier Ireland Ltd. ă All rights reserved.

Keywords: Quality (search for similar items in EconPapers)
Date: 2016-05
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Citations: View citations in EconPapers (1)

Published in Psychiatry Research, 2016, 239, pp.301-307. ⟨10.1016/j.psychres.2016.03.038⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482524

DOI: 10.1016/j.psychres.2016.03.038

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