Gut microbiota analysis reveals a marked shift to bifidobacteria by a ă starter infant formula containing a synbiotic of bovine milk-derived ă oligosaccharides and Bifidobacterium animalis subsp lactisCNCM I-3446

Umberto Simeoni, Bernard Berger, Jana Junick, Michael Blaut, Sophie Pecquet, Enea Rezzonico, Dominik Grathwohl, Norbert Sprenger, Harald Brussow, Hania Szajewska, J-M. Bartoli, V. Brevaut-Malaty, M. Borszewska-Kornacka, W. Feleszko, P. François, C. Gire (), M. Leclaire, J-M. Maurin, S. Schmidt, A. Skorka, C. Squizzaro, J-J. Verdot and Study Team
Additional contact information
Umberto Simeoni: VRCM - Vascular research center of Marseille - AMU - Aix Marseille Université - INSERM - Institut National de la Santé et de la Recherche Médicale, Service de Médecine Néonatale - APHM - Assistance Publique - Hôpitaux de Marseille
Bernard Berger: Nestlé Research Center | Centre de recherche Nestlé [Lausanne] - Nestlé S.A.
Michael Blaut: Gastrointestinal Microbiology [Nuthetal] - DIfE - German Institute of Human Nutrition Potsdam-Rehbrücke
Hania Szajewska: Department of Paediatrics - Warszawski Uniwersytet Medyczny [Polska] = Medical University of Warsaw [Poland] = Université de Médecine de Varsovie [Pologne]
V. Brevaut-Malaty: Département de Pédiatrie-Néonatologie - APHM - Assistance Publique - Hôpitaux de Marseille - Hôpital Nord [CHU - APHM]
P. François: Centre de prothonthérapie d'Orsay Institut Curie - Institut Curie [Paris]
C. Gire: Département de Pédiatrie-Néonatologie - APHM - Assistance Publique - Hôpitaux de Marseille - Hôpital Nord [CHU - APHM]

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Abstract: Non-digestible milk oligosaccharides were proposed as receptor decoys ă for pathogens and as nutrients for beneficial gut commensals like ă bifidobacteria. Bovine milk contains oligosaccharides, some of which are ă structurally identical or similar to those found in human milk. In a ă controlled, randomized double-blinded clinical trial we tested the ă effect of feeding a formula supplemented with a mixture of bovine ă milk-derived oligosaccharides (BMOS) generated from whey permeate, ă containing galacto-oligosaccharides and 3'- and 6'-sialyllactose, and ă the probiotic Bifidobacterium animalis subsp. lactis (B.lactis) strain ă CNCM I-3446. Breastfed infants served as reference group. Compared with ă a non-supplemented control formula, the test formula showed a similar ă tolerability and supported a similar growth in healthy newborns followed ă for 12 weeks. The control, but not the test group, differed from the ă breast-fed reference group by a higher faecal pH and a significantly ă higher diversity of the faecal microbiota. In the test group the ă probiotic B.lactis increased by 100-fold in the stool and was detected ă in all supplemented infants. BMOS stimulated a marked shift to a ă bifidobacterium-dominated faecal microbiota via increases in endogenous ă bifidobacteria (B.longum, B.breve, B.bifidum, B.pseudocatenulatum).

Keywords: Quality; of; Life (search for similar items in EconPapers)
Date: 2016-07
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Published in Environmental Microbiology, 2016, 18 (7, SI), pp.2185-2195. ⟨10.1111/1462-2920.13144⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482639

DOI: 10.1111/1462-2920.13144

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