HLA-E*01:03 Allele in Lung Transplant Recipients Correlates with ă Higher Chronic Lung Allograft Dysfunction Occurrence

Julie Di Cristofaro, Mathieu Pelardy, Anderson Loundou, Agnès Basire, Carine Gomez, Jacques Chiaroni (), Pascal Thomas, Martine Reynaud-Gaubert and Christophe Picard
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Julie Di Cristofaro: EFS - Alpes-Méditerranée - Etablissement Français du Sang - Alpes-Méditerranée - Etablissement Français du Sang, ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé - AMU - Aix Marseille Université - EFS ALPES MEDITERRANEE - CNRS - Centre National de la Recherche Scientifique
Anderson Loundou: Unité d'Aide Méthodologique - APHM - Assistance Publique - Hôpitaux de Marseille - CHU Marseille
Agnès Basire: ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé - AMU - Aix Marseille Université - EFS ALPES MEDITERRANEE - CNRS - Centre National de la Recherche Scientifique, EFS - Alpes-Méditerranée - Etablissement Français du Sang - Alpes-Méditerranée - Etablissement Français du Sang
Carine Gomez: Hôpital Nord [CHU - APHM]
Jacques Chiaroni: EFS - Alpes-Méditerranée - Etablissement Français du Sang - Alpes-Méditerranée - Etablissement Français du Sang, ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé - AMU - Aix Marseille Université - EFS ALPES MEDITERRANEE - CNRS - Centre National de la Recherche Scientifique
Pascal Thomas: Hôpital Nord [CHU - APHM]
Martine Reynaud-Gaubert: Hôpital Nord [CHU - APHM]
Christophe Picard: EFS - Alpes-Méditerranée - Etablissement Français du Sang - Alpes-Méditerranée - Etablissement Français du Sang, ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé - AMU - Aix Marseille Université - EFS ALPES MEDITERRANEE - CNRS - Centre National de la Recherche Scientifique

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Abstract: Lung transplantation (LTx) is a valid therapeutic option for selected ă patients with end-stage lung disease. HLA-E seems to play a major role ă in the immune response to different viral infections and to affect ă transplantation outcome, in Hematopoietic Stem Cell Transplantation, for ă example. Two nonsynonymous alleles, HLA-E*01:01 and HLA-E*01: 03, ă have functional differences, involving relative peptide affinity, cell ă surface expression, and potential lytic activity of NK cells. The aim of ă this retrospective study was to determine the impact of these two ă alleles for LTx recipients on anti-HLA alloimmunization risk, overall ă survival, and chronic rejection (CLAD). HLA-E was genotyped in 119 ă recipients who underwent LTx from 1998 to 2010 in a single ă transplantation center. In univariate analysis, both HLA-E homozygous ă states were associated with impaired overall survival compared to ă heterozygous HLA-E alleles (p = 0.01). In multivariate analysis, ă HLA-E*01:03 allele showed increased CLAD occurrence when compared to ă homozygous HLA-E*01:01 status (HR: 3.563 (CI 95%, 1.016-12), p = ă 0.047). HLA-E allele did not affect pathogen infection or the production ă of de novo DSA. This retrospective study shows an uninvestigated, ă deleterious association of HLA-E alleles with LTx and requires ă verification using a larger cohort.

Keywords: Quality; of; Life (search for similar items in EconPapers)
Date: 2016
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Published in Journal of Immunology Research, 2016

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01482652

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