Using multi-criteria decision analysis to appraise orphan drugs: a systematic review

Carlotta Friedmann, Pierre Lévy, Paul Hensel and Mickaël Hiligsmann
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Pierre Lévy: LEDa - Laboratoire d'Economie de Dauphine - Université Paris Dauphine-PSL - PSL - Université Paris Sciences et Lettres, Legos - Laboratoire d'Economie et de Gestion des Organisations de Santé - Université Paris Dauphine-PSL - PSL - Université Paris Sciences et Lettres

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Abstract: Multi-criteria decision analysis (MCDA) could potentially solve current methodological difficulties in the appraisal of orphan drugs. Areas covered: We provide an overview of the existing evidence regarding the use of MCDA in the appraisal of orphan drugs worldwide. Three databases (Pubmed, Embase, Web of Science) were searched for English, French and German literature published between January 2000 and April 2017. Full-text articles were supplemented with conference abstracts. A total of seven articles and six abstracts were identified. Expert commentary: The literature suggests that MCDA is increasingly being used in the context of appraising orphan drugs. It has shown itself to be a flexible approach with the potential to assist in decision-making regarding reimbursement for orphan drugs. However, further research regarding its application must be conducted.

Keywords: MCDA; Multi-criteria decision analysis; appraisal; orphan drugs; rare diseases; reimbursement; systematic review (search for similar items in EconPapers)
Date: 2017
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Published in Expert Review of Pharmacoeconomics and Outcomes Research, 2017, ⟨10.1080/14737167.2018.1414603⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-01713328

DOI: 10.1080/14737167.2018.1414603

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