The indigenous South American Tsimane exhibit relatively modest decrease in brain volume with age despite high systemic inflammation

Andrei Irimia, Nikhil Chaudhari, David Robles, Kenneth Rostowsky, Alexander Maher, Nahian Chowdhury, Maria Calvillo, Ngo Long, Margaret Gatz, Wendy Mack, Meng Law, Linda Sutherland, James Sutherland, Christophe J. Rowan, Samuel Wann, Adel Allam, Randall Thompson, David Michalik, Daniel Cummings, Edmond Seabright, Sarah Alami, Angela Garcia, Paul L. Hooper, Jonathan Stieglitz, Benjamin C. Trumble, Michael Gurven, Gregory Thomas, Caleb Finch and Hillard Kaplan
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Meng Law: Unknown
Jonathan Stieglitz: IAST - Institute for Advanced Study in Toulouse
Hillard Kaplan: IAST - Institute for Advanced Study in Toulouse

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Abstract: Brain atrophy is correlated with risk of cognitive impairment, functional decline, and dementia. Despite a high infectious disease burden, Tsimane forager-horticulturists of Bolivia have the lowest prevalence of coronary atherosclerosis of any studied population and present few cardiovascular disease (CVD) risk factors despite a high burden of infections and therefore inflammation. This study (A) examines the statistical association between brain volume and age for Tsimane, and (B) compares this association to that of three industrialized populations in the U.S. and Europe. This cohort-based panel study enrolled 746 participants aged 40 to 94 (396 males), from whom computed tomography (CT) head scans were acquired. Brain volume (BV) and intracranial volume (ICV) were calculated from automatic head CT segmentations.

Date: 2021-12
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Published in Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2021, vol. 76 (n° 12), pp.2147-2155. ⟨10.1093/gerona/glab138⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-03449914

DOI: 10.1093/gerona/glab138

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