Are patients living far from hospital at higher risk of late adjuvant chemotherapy for colon cancer?

Thomas Vermeulin, Hana Lahbib, Mélodie Lucas, Pierre Czernichow, Florence Jusot, Frédéric Di Fiore and Véronique Merle
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Thomas Vermeulin: Service d'informatique biomédicale [Rouen] - CHU Rouen - NU - Normandie Université - UNIROUEN - Université de Rouen Normandie - NU - Normandie Université
Frédéric Di Fiore: Service d'Hépato-Gastroentérologie [CHU Rouen] - Hôpital Charles Nicolle [Rouen] - CHU Rouen - NU - Normandie Université - CHU Rouen - NU - Normandie Université - UNIROUEN - Université de Rouen Normandie - NU - Normandie Université, Service de Chirurgie Digestive [CHU Rouen] - CHU Rouen - NU - Normandie Université - UNIROUEN - Université de Rouen Normandie - NU - Normandie Université, CBG - Cancer and Brain Genomics - UNIROUEN - Université de Rouen Normandie - NU - Normandie Université - IRIB - Institute for Research and Innovation in Biomedicine - UNIROUEN - Université de Rouen Normandie - NU - Normandie Université - INSERM - Institut National de la Santé et de la Recherche Médicale - CNRS - Centre National de la Recherche Scientifique - INSERM - Institut National de la Santé et de la Recherche Médicale
Véronique Merle: Département d'épidémiologie et de promotion de la santé [Rouen] - CHU Rouen - NU - Normandie Université - UNIROUEN - Université de Rouen Normandie - NU - Normandie Université, ANTICIPE - Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers - UNICAEN - Université de Caen Normandie - NU - Normandie Université - CHU Caen - NU - Normandie Université - TCBN - Tumorothèque de Caen Basse-Normandie - UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen] - NU - Normandie Université - UNICANCER - TCBN - Tumorothèque de Caen Basse-Normandie - INSERM - Institut National de la Santé et de la Recherche Médicale

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Abstract: AimsLate adjuvant chemotherapy (aCT) administration after colectomy (>56 d) is known to be associated with impaired prognosis. We aim to identify risk factors associated with late aCT, especially the travel time between patients' home and hospital.MethodsWe performed a retrospective monocentre cohort study. Patients included had a colectomy for a stage III or high risk stage II colon cancer between 2009 and 2015 performed at a French university hospital. Risk factors for late aCT were identified using a fractional polynomial logistic regression.ResultsNinety-four patients were included. The risk of late aCT was associated with travel time length, emergent colectomy, the need for scheduled care before aCT, and length of time between colectomy and postoperative multidisciplinary meeting advising aCT.ConclusionOur study suggests that, in patients with colon cancer, factors unrelated to disease severity and complexity could be associated with a higher risk of late aCT.

Keywords: adjuvant chemotherapy; colonic neoplasms; health services accessibility; time to treatment (search for similar items in EconPapers)
Date: 2022
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Published in British Journal of Clinical Pharmacology, 2022, 88 (8)

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-03964708

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