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Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists

Margaret Gatz, Wendy Mack, Helena Chui, Meng Law, Giuseppe Barisano, Linda Sutherland, James Sutherland and Jonathan Stieglitz
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Margaret Gatz: Unknown
Wendy Mack: Unknown
Helena Chui: Unknown
Meng Law: Unknown
Giuseppe Barisano: Unknown
Linda Sutherland: Unknown
James Sutherland: Unknown

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Abstract: We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. Methods : Participants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans. Results : Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age-standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia. Discussion : The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non-Alzheimer's disease (AD) dementia phenotype.

Date: 2023-01
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Published in Alzheimer's and Dementia, 2023, vol. 19 (n° 1), pp.44-55. ⟨10.1002/alz.12626⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-04067662

DOI: 10.1002/alz.12626

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