Increases in regional brain volume across two native South American male populations

Nikhil Chaudhari, Phoebe E. Imms, Nahian Chowdhury, Margaret Gatz, Benjamin C. Trumble, Wendy Mack, Meng Law, Linda Sutherland, James Sutherland, Christophe J. Rowan, L. Samuel Wann, Adel H. Allam, Randall C. Thompson, David E. Michalik, Michael I. Miyamoto, Guido Lombardi, Daniel Cummings, Edmond Seabright, Sarah Alami, Angela Garcia, Daniel Rodriguez, Raul Quispe Gutierrez, Adrian Juan Copajira, Paul L. Hooper, Kenneth Buetow, Jonathan Stieglitz (), Michael Gurven, Gregory Thomas, Hillard Kaplan, Caleb Finch and Andrei Irimia
Additional contact information
Nikhil Chaudhari: USC - University of Southern California
Phoebe E. Imms: USC - University of Southern California
Nahian Chowdhury: USC - University of Southern California
Margaret Gatz: USC - University of Southern California
Benjamin C. Trumble: ASU - Arizona State University [Tempe]
Wendy Mack: USC - University of Southern California
Meng Law: Monash university
Linda Sutherland: MemorialCare Health Systems, Fountain Valley, California
James Sutherland: MemorialCare Health Systems, Fountain Valley, California
Christophe J. Rowan: University of Nevada [Reno]
L. Samuel Wann: The University of New Mexico [Albuquerque] - NMC - New Mexico Consortium
Adel H. Allam: Al-Azhar University [Cairo, Egypt]
Randall C. Thompson: University of Central Missouri
David E. Michalik: UC - University of California
Michael I. Miyamoto: Mission Heritage Medical Group, Providence Health, Mission Viejo,
Guido Lombardi: UPCH - Universidad Peruana Cayetano Heredia - Peruvian University Cayetano Heredia [Lima, Peru]
Daniel Cummings: The University of New Mexico [Albuquerque] - NMC - New Mexico Consortium
Edmond Seabright: The University of New Mexico [Albuquerque] - NMC - New Mexico Consortium
Sarah Alami: The University of New Mexico [Albuquerque] - NMC - New Mexico Consortium
Angela Garcia: ASU - Arizona State University [Tempe]
Daniel Rodriguez: San Simon University, Cochabamba, Bolivia
Raul Quispe Gutierrez: Tsimane Health and Life History Project, San Borja, Bolivia
Adrian Juan Copajira: Tsimane Health and Life History Project, San Borja, Bolivia
Paul L. Hooper: The University of New Mexico [Albuquerque] - NMC - New Mexico Consortium
Kenneth Buetow: ASU - Arizona State University [Tempe]
Jonathan Stieglitz: TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - Comue de Toulouse - Communauté d'universités et établissements de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement
Michael Gurven: UC - University of California
Gregory Thomas: Division of Cardiology, University of California, Irvine, Orange
Hillard Kaplan: Chapman University
Caleb Finch: USC - University of Southern California
Andrei Irimia: USC - University of Southern California

Post-Print from HAL

Abstract: Industrialized environments, despite benefits such as higher levels of formal education and lower rates of infections, can also have pernicious impacts upon brain atrophy. Partly for this reason, comparing age-related brain volume trajectories between industrialized and non-industrialized populations can help to suggest lifestyle correlates of brain health. The Tsimane, indigenous to the Bolivian Amazon, derive their subsistence from foraging and horticulture and are physically active. The Moseten, a mixed-ethnicity farming population, are physically active but less than the Tsimane. Within both populations (N = 1024; age range = 46–83), we calculated regional brain volumes from computed tomography and compared their cross-sectional trends with age to those of UK Biobank (UKBB) participants (N = 19,973; same age range). Surprisingly among Tsimane and Moseten (T/M) males, some parietal and occipital structures mediating visuospatial abilities exhibit small but significant increases in regional volume with age. UKBB males exhibit a steeper negative trend of regional volume with age in frontal and temporal structures compared to T/M males. However, T/M females exhibit significantly steeper rates of brain volume decrease with age compared to UKBB females, particularly for some cerebro-cortical structures (e.g., left subparietal cortex). Across the three populations, observed trends exhibit no interhemispheric asymmetry. In conclusion, the age-related rate of regional brain volume change may differ by lifestyle and sex. The lack of brain volume reduction with age is not known to exist in other human population, highlighting the putative role of lifestyle in constraining regional brain atrophy and promoting elements of non-industrialized lifestyle like higher physical activity.

Keywords: Brain aging; Neurodegeneration; Cortex (search for similar items in EconPapers)
Date: 2024-04-29
Note: View the original document on HAL open archive server: https://hal.science/hal-04908016v1
References: View complete reference list from CitEc
Citations:

Published in GeroScience, 2024, 46, pp.4563-4583. ⟨10.1007/s11357-024-01168-2⟩

Downloads: (external link)
https://hal.science/hal-04908016v1/document (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-04908016

DOI: 10.1007/s11357-024-01168-2

Access Statistics for this paper

More papers in Post-Print from HAL
Bibliographic data for series maintained by CCSD ().