Nonuniversality of inflammaging across human populations

Maximilien Franck, Kamaryn T. Tanner, Robert L. Tennyson, Camille Daunizeau, Luigi Ferrucci, Stefania Bandinelli, Benjamin C. Trumble, Hillard Kaplan, Jacob E. Aronoff, Jonathan Stieglitz, Thomas S. Kraft, Amanda J. Lea, Vivek Venkataraman, Ian J. Wallace, Yvonne A.L. Lim, Kee Seong Ng, Joe Poh Sheng Yeong, Roger C. Ho, Xinru Lim, Ameneh Mehrjerd, Eleftheria G. Charalambous, Allison E. Aiello, Graham Pawelec, Claudio Franceschi, Johannes Hertel, Tamàs Fülöp, Maël Lemoine, Michael Gurven and Alan A. Cohen
Additional contact information
Maximilien Franck: CIREQ - Centre Interuniversitaire de Recherche en Economie Quantitative
Kamaryn T. Tanner: Columbia University [New York]
Robert L. Tennyson: Vanderbilt University [Nashville], University of Utah
Camille Daunizeau: Laval University, Quebec, Canada
Luigi Ferrucci: NIH National Institute on Aging
Stefania Bandinelli: Azienda Sanitaria di Firenze
Benjamin C. Trumble: ASU - Arizona State University [Tempe]
Hillard Kaplan: TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - UT - Université de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, Chapman University
Jacob E. Aronoff: ASU - Arizona State University [Tempe]
Jonathan Stieglitz: TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - UT - Université de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement
Thomas S. Kraft: University of Utah
Amanda J. Lea: Vanderbilt University [Nashville]
Vivek Venkataraman: TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - UT - Université de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, University of Calgary
Ian J. Wallace: The University of New Mexico [Albuquerque] - NMC - New Mexico Consortium
Yvonne A.L. Lim: UM - University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie]
Kee Seong Ng: UM - University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie]
Joe Poh Sheng Yeong: A*STAR - Agency for science, technology and research [Singapore], Singapore General Hospital, NUS - National University of Singapore
Roger C. Ho: NUS - National University of Singapore
Xinru Lim: A*STAR - Agency for science, technology and research [Singapore]
Ameneh Mehrjerd: Universität Greifswald = University of Greifswald
Eleftheria G. Charalambous: Universität Greifswald = University of Greifswald
Allison E. Aiello: Columbia University [New York]
Graham Pawelec: Eberhard Karls Universität Tübingen = University of Tübingen, Health Sciences North Research Institute [Sudbury]
Claudio Franceschi: National Research Lobachevsky State University of Nizhni Novgorod
Johannes Hertel: Universität Greifswald = University of Greifswald, German Centre for Cardiovascular Research (DZHK) partner site Berlin - DZHK - German Center for Cardiovascular Research - BIH - Berlin Institute of Health
Tamàs Fülöp: CIREQ - Centre Interuniversitaire de Recherche en Economie Quantitative
Maël Lemoine: INSB-CNRS - Institut des sciences biologiques - CNRS Biologie
Michael Gurven: UC Santa Barbara - University of California [Santa Barbara] - UC - University of California
Alan A. Cohen: CIREQ - Centre Interuniversitaire de Recherche en Economie Quantitative, Columbia University [New York]

Post-Print from HAL

Abstract: Inflammaging, an age-associated increase in chronic inflammation, is considered a hallmark of aging. However, there is no consensus approach to measuring inflammaging based on circulating cytokines. Here we assessed whether an inflammaging axis detected in the Italian InCHIANTI dataset comprising 19 cytokines could be generalized to a different industrialized population (Singapore Longitudinal Aging Study) or to two indigenous, nonindustrialized populations: the Tsimane from the Bolivian Amazon and the Orang Asli from Peninsular Malaysia. We assessed cytokine axis structure similarity and whether the inflammaging axis replicating the InCHIANTI result increased with age or was associated with health outcomes. The Singapore Longitudinal Aging Study was similar to InCHIANTI except for IL-6 and IL-1RA. The Tsimane and Orang Asli showed markedly different axis structures with little to no association with age and no association with age-related diseases. Inflammaging, as measured in this manner in these cohorts, thus appears to be largely a byproduct of industrialized lifestyles, with major variation across environments and populations.

Keywords: Ageing; Cytokines; Inflammation; Predictive markers (search for similar items in EconPapers)
Date: 2025-06-30
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Published in Nature Aging, 2025, ⟨10.1038/s43587-025-00888-0⟩

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Persistent link: https://EconPapers.repec.org/RePEc:hal:journl:hal-05143941

DOI: 10.1038/s43587-025-00888-0

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