OECD Series on Adverse Outcome Pathways

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42: Adverse Outcome Pathway on Deposition of Energy Leading to Learning and Memory Impairment

Ahmad Sleiman, Kathleen Miller, Danicia Flores, Jacqueline Kuan, Kaitlyn Altwasser, Benjamin Smith, Hailey Adams, Tatiana Kozbenko, Robyn Hocking, Carole Yauk, Ruth Wilkins and Vinita Chauhan

41: Adverse Outcome Pathway on Deposition of Energy Leading to Occurrence of Bone Loss

Snehpal Sandhu, Mitchell Keyworth, Syna Karimi-Jashni, Dalya Alomar, Benjamin Smith, Tatiana Kozbenko, Robyn Hocking, Carole Yauk, Ruth C. Wilkins and Vinita Chauhan

40: Adverse Outcome Pathway on Deposition of Energy Leading to Cataracts

Emma Carrothers, Meghan Appleby, Vita Lai, Tatiana Kozbenko, Dalya Alomar, Benjamin Smith, Robyn Hocking, Carole Yauk, Ruth Wilkins and Vinita Chauhan

39: Adverse Outcome Pathway on Deposition of Energy Leading to Abnormal Vascular Remodeling

Tatiana Kozbenko, Nadine Adam, Veronica Grybas, Benjamin Smith, Dalya Alomar, Robyn Hocking, Janna Abdelaziz, Amanda Pace, Carole Yauk, Ruth Wilkins and Vinita Chauhan

38: Adverse Outcome Pathway on Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity

Prarthana Shankar and Dan Villeneuve

37: Adverse Outcome Pathway on Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development

Prarthana Shankar and Dan Villeneuve

36: Adverse Outcome Pathway on Binding to voltage gate sodium channels during development leading to cognitive impairment

Iris Mangas, Antonio F. Hernandez, Kevin Crofton, Mary Gilbert, Martin Paparella, Anna Price, Tim Shafer, Laura Martino, Martina Panzarea and Andrea Terron

35: Adverse Outcome Pathway on Androgen receptor agonism leading to male-biased sex ratio

Kelvin J. Santana Rodriguez, Daniel L. Villeneuve, Kathleen M. Jensen, Gerald T. Ankley and David H. Miller

34: Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation

Kelvin J. Santana Rodriguez, Daniel L. Villeneuve, Kathleen M. Jensen, Gerald T. Ankley and David H. Miller

33: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis

Sabina Halappanavar, Monita Sharma, Silvia Solorio-Rodriguez, Hakan Wallin, Ulla Vogel, Kristie Sullivan and Amy J. Clippinger

32: Adverse Outcome Pathway on deposition of energy leading to lung cancer

Samantha Sherman, Zakara Said, Baki Sadi, Carole Yauk, Danielle Beaton, Ruth Wilkins, Robert Stainforth, Nadine Adam and Vinita Chauhan

31: Disruption of VEGFR signaling leading to developmental defects

Thomas B. Knudsen, Katerine Saili, Jill Franzosa, Nancy Baker, Richard Spencer, Tamara Tal, Nicole Kleinstreuer, Tuula Heinonen, Rob Ellis-Hutchings, Neil Vargesson and Maria Bondesson

30: Adverse Outcome Pathway on impaired interleukin-1 receptor type I (IL-1R1) signaling leading to impaired T-cell dependent antibody response

Yutaka Kimura, Setsuya Aiba, Takao Ashikaga, Takumi Ohishi and Kiyoshi Kushima

29: Oxidative DNA damage leading to chromosomal aberrations and mutations

Eunnara Cho, Ashley Allemang, Marc Audebert, Vinita Chauhan, Stephen Dertinger, Giel Hendriks, Mirjam Luijten, Francesco Marchetti, Sheroy Minocherhomji, Stefan Pfuhler, Daniel J. Roberts, Kristina Trenz and Carole L. Yauk

28: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation

You Song and Daniel L. Villeneuve

27: Chitin synthase 1 inhibition leading to mortality

Simon Schmid, You Song and Knut Erik Tollefsen

26: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation

Lucia Vergauwen, Evelyn Stinckens, Daniel L. Villeneuve and Dries Knapen

25: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation

Lucia Vergauwen, Evelyn Stinckens, Daniel L. Villeneuve and Dries Knapen

24: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation

Lucia Vergauwen, Evelyn Stinckens, Daniel L. Villeneuve and Dries Knapen

23: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation

Lucia Vergauwen, Evelyn Stinckens, Daniel L. Villeneuve and Dries Knapen

22: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation

Lucia Vergauwen, Evelyn Stinckens, Daniel L. Villeneuve and Dries Knapen

21: Inhibitor binding to topoisomerase II leading to infant leukaemia

Olavi Pelkonen, Andrea Terron, Antonio F. Hernandez, Pablo Menendez and Susanne Hougaard Bennekou

20: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leading to impairment of learning and memory

Florianne Tschudi-Monnet, Marie-Gabrielle Zurich, Carolina Nunes, Jenny Sandström, Rex FitzGerald, Michael Aschner and Joao Rocha

19: Adverse Outcome Pathway on Cyp2E1 activation leading to liver cancer

Francina Webster, Iain B. Lambert and Carole L. Yauk

18: Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T-cell dependent antibody response

Hiroyuki Komatsu, Junichiro Sugimoto, Ken Goto, Kiyoshi Kushima, Naohisa Tsutsui, Shigeru Hisada, Shiho Ito, Tadashi Kosaka, Takumi Ohishi, Yasuharu Otsubo and Yoshihiro Takahashi

17: Adverse Outcome Pathway on histone deacetylase inhibition leading to testicular atrophy

Shihori Tanabe, Akihiko Hirose and Takashi Yamada

16: Adverse Outcome Pathway on Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF

Amani Farhat and Sean W. Kennedy

15: Adverse Outcome Pathway on Aryl hydrocarbon receptor activation leading to uroporphyria

Amani Farhat, Gillian Manning, Jason O’Brien and Sean W. Kennedy

14: Adverse Outcome Pathway on inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment

Alexandra Rolaki, Francesca Pistollato, Sharon Munn and Anna Bal-Price

13: Adverse Outcome Pathway on inhibition of Thyroperoxidase and subsequent adverse neurodevelopmental outcomes in mammals

Kevin M. Crofton, Mary Gilbert, Katie Paul Friedman, Barbara Demeneix, Mary Sue Marty and R. Thomas Zoeller

12: Adverse Outcome Pathway on aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2

Jon Doering, Markus Hecker, Daniel L. Villeneuve and Xiaowei Zhang

11: Adverse Outcome Pathway on binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain

Ping Gong and Edward J. Perkins

10: Adverse Outcome Pathway on antagonist binding to PPARα leading to body-weight loss

Kurt A. Gust, Mitchell S. Wilbanks, Zachary A. Collier, Lyle D. Burgoon and Edward J. Perkins

9: Adverse Outcome Pathway on Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)

Daniel L. Villeneuve

8: Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D-aspartate receptors during brain development leading to neurodegeneration with impairment in learning and memory in aging

Florianne Tschudi-Monnet and Rex FitzGerald

7: Adverse Outcome Pathway on Inhibition of the mitochondrial complex I of nigro-striatal neurons leading to parkinsonian motor deficits

Anna Bal-Price, Marcel Leist, Stefan Schildknecht, Florianne Tschudi-Monnet, Alicia Paini and Andrea Terron

6: Adverse Outcome Pathway on binding of agonists to ionotropic glutamate receptors in adult brain leading to excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment

Magdalini Sachana, Sharon Munn and Anna Bal-Price

5: Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities

Magdalini Sachana, Sharon Munn and Anna Bal-Price

4: Adverse Outcome Pathway on Aromatase Inhibition Leading to Reproductive Dysfunction (in Fish)

Daniel L. Villeneuve

3: Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations

Carole Yauk, Iain Lambert, Francesco Marchetti and George Douglas

2: Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis

Brigitte Landesmann

1: Users' Handbook supplement to the Guidance Document for developing and assessing Adverse Outcome Pathways

Oecd