Insights and limits of translational research in critical care medicine

Frédéric Pène, Hafid Ait-Oufella, Fabio Taccone, Guillaume Monneret, Tarek Sharshar, Fabienne Tamion and Jean-Paul Mira

ULB Institutional Repository from ULB -- Universite Libre de Bruxelles

Abstract: Experimental research has always been the cornerstone of pathophysiological and therapeutic advances in critical care medicine, where clinical observations and basic research mutually fed each other in a so-called translational approach. The objective of this review is to address the different aspects of translational research in the field of critical care medicine. We herein highlighted some demonstrative examples including the animal-to-human approach to study host-pathogen interactions, the human-to-animal approach for sepsis-induced immunosuppression, the still restrictive human approach to study critical illness-related neuromyopathy, and the technological developments to assess the microcirculatory changes in critically ill patients. These examples not only emphasize how translational research resulted in major improvements in the comprehension of the pathophysiology of severe clinical conditions and offered promising perspectives in critical care medicine but also point out the obstacles to translate such achievements into clinical practice.

Keywords: Critical care medicine; Critical illness-related neuromyopathy; Microcirculation; Sepsis; Translational research (search for similar items in EconPapers)
Date: 2015-12
Note: SCOPUS: ar.j
References: View complete reference list from CitEc
Citations:

Published in: Annals of intensive care (2015) v.5 n° 1

Downloads: (external link)
https://dipot.ulb.ac.be/dspace/bitstream/2013/205692/3/doi_189319.pdf Full text for the whole work, or for a work part (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:ulb:ulbeco:2013/205692

Ordering information: This working paper can be ordered from
http://hdl.handle.ne ... lb.ac.be:2013/205692

Access Statistics for this paper

More papers in ULB Institutional Repository from ULB -- Universite Libre de Bruxelles Contact information at EDIRC.
Bibliographic data for series maintained by Benoit Pauwels ().