Dyspnea as a marker of prognosis in immunocompromised patients with acute respiratory failure

Alexandre Demoule, Maxens Decavèle, Sangeeta Mehta, Philippe P.R. Bauer, Victoria Metaxa, Frédéric Pène, Christophe Girault, Laveena Munshi, Fabio Silvio Taccone, Massimo Antonelli, François Barbier, Andreas Barratt-Due, Gastón Burghi, Emmanuel Canet, Achille Kouatchet, Virginie Lemiale, Ignacio Martin-Loeches, Djamel Mokart, Anne Sophie Moreau, Luca Montini, Peter Pickkers, Jordi Rello, Peter Schellongowski, Nicolas Terzi, Miia Valkonen, Andry van de Louw, Elie Azoulay and Michael Darmon

ULB Institutional Repository from ULB -- Universite Libre de Bruxelles

Abstract: Background Acute hypoxemic respiratory failure (AHRF) is the leading cause of intensive care unit (ICU) admission in immunocompromised patients, in whom both intubation and mortality rates are higher than in the general ICU population. This study explores dyspnea on admission as it relates to clinical outcomes. Methods Secondary analysis of the Efraim study, a prospective multinational cohort study of immunocompromised patients with AHRF admitted to the ICU. Dyspnea was quantified by a numeric rating scale (dyspnea-NRS) from zero to 10. Factors associated with dyspnea-NRS were assessed with linear regression. Hierarchical model was used to assess factors independently associated with invasive mechanical ventilation (intubation) and hospital mortality. Results 547 patients were included. On ICU admission, median dyspnea-NRS was 5 (interquartile range 4–7). Variables independently associated with dyspnea-NRS were underlying immune defect unrelated to hematological malignancy, chronic heart failure, high SOFA score and respiratory rate. Intubation rate was 41 %. Variables independently associated with intubation were dyspnea-NRS ≥5 (odds ratio [OR] 2.61, p

Keywords: Acute respiratory failure; Comfort; Diagnosis; Dyspnea; High flow oxygen; Immunocompromised; Intubation; Mechanical ventilation; Non-invasive ventilation; Outcome. (search for similar items in EconPapers)
Date: 2026-01
Note: SCOPUS: ar.j
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Published in: Annals of intensive care (2026) v.16

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