Estimation of genetic parameters using molecular markers and EM-algorithms

Katharina Emrich and Urfer Wolfgang

No 1999,48, Technical Reports from Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen

Abstract: In this paper we present a new method for estimating genetic parameters of an F2- generation model. Using an iterative algorithm we derive explicit expressions for the Maximum Likelihood estimates of the additive and dominance effects. Finally we calculate the variance covariance matrix of our Maximum Likelihood estimates, which enables us to determine a confidence interval for the location of a quantitative trait locus.

Keywords: molecular genetics; Maximum Likelihood estimation; EM and ECM algorithms; variance-and covariance matrix of Maximum Likelihood estimates; confidence intervals for genetic parameters (search for similar items in EconPapers)
Date: 1999
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Persistent link: https://EconPapers.repec.org/RePEc:zbw:sfb475:199948

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