Statistical analysis of sequence-structure alignment scores

Marcus Brunnert, Ralf Thiele, Heinz-Theodor Mevissen and Wolfgang Urfer

No 2002,38, Technical Reports from Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen

Abstract: The structural analysis of proteins is fundamental to the analysis of protein functions. In this context, sequence-structure alignment methods are important among the different empirical methods. In order to assess the quality of sequence-structure alignments, a statistical method using a Bayesian approach proposed by Lathrop et al. (1998) will be presented. Finally, the results of a developed statistical analysis of scores of RDP(recursive dynamic programming)-sequence-structure alignments (Thiele et al., 1999) according to data of six proteins will be described.

Keywords: Sequence-structure-alignment; statistically significant scores; Combined Bayesian approach and RDP-alignment (search for similar items in EconPapers)
Date: 2002
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Persistent link: https://EconPapers.repec.org/RePEc:zbw:sfb475:200238

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