Estimation of the mean AUC of the xenoestrogens daidzein, bisphenol A, and p-tert-octylphenol

Silvia Selinski and Gisela H. Degen

No 2003,05, Technical Reports from Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen

Abstract: Potentially adverse human and environmental effects due to hormone mimicry of environmental estrogens are a matter of current concern. Environmental estrogens belong to the so-called endocrine active compounds (EAC), which alter signalling processes of the endocrine system leading to a broad range of effects during foetal and postnatal development, puberty, adulthood, and aging. A number of synthetic chemicals as well as several plant-derived compounds, so-called phytoestrogens, are known to have weak estrogenic activity. The present study is part of the risk assessment of the weak environmental estrogens daidzein, p-tert-octylphenol, and bisphenol A. The isoflavone daidzein is an important phytoestrogen with respect to dietary exposure (soy beans and soy products). p-tert-Octylphenol and bisphenol A are industrial chemicals. The toxicokinetics and the bioavailability of these three substances in female DA/Han rats after oral and single intravenous application were investigated by the use of population models accounting for the differences in the individual metabolism. Furthermore, populations of pregnant and non-pregnant rats are compared.

Keywords: Bisphenol A; daidzein; p-tert-octylphenol; xenoestrogens; phytoestrogens; endocrine active compounds; bioavailability; AUC; population model; EM algorithm; Mann-Whitney-U-test (search for similar items in EconPapers)
Date: 2003
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Citations: View citations in EconPapers (1)

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