Control of the False Discovery Rate under Dependence using the Bootstrap and Subsampling

Joseph P. Romano, Azeem Shaikh and Michael Wolf

No 337, IEW - Working Papers from Institute for Empirical Research in Economics - University of Zurich

Abstract: This paper considers the problem of testing s null hypotheses simultaneously while controlling the false discovery rate (FDR). Benjamini and Hochberg (1995) provide a method for controlling the FDR based on p-values for each of the null hypotheses under the assumption that the p-values are independent. Subsequent research has since shown that this procedure is valid under weaker assumptions on the joint distribution of the p-values. Related procedures that are valid under no assumptions on the joint distribution of the p-values have also been developed. None of these procedures, however, incorporate information about the dependence structure of the test statistics. This paper develops methods for control of the FDR under weak assumptions that incorporate such information and, by doing so, are better able to detect false null hypotheses. We illustrate this property via a simulation study and two empirical applications. In particular, the bootstrap method is competitive with methods that require independence if independence holds, but it outperforms these methods under dependence.

Keywords: Bootstrap; Subsampling; False Discovery Rate; Multiple Testing; Stepdown Procedure. (search for similar items in EconPapers)
JEL-codes: C12 C14 (search for similar items in EconPapers)
Date: 2008-12
New Economics Papers: this item is included in nep-ecm
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (36)

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Journal Article: Control of the false discovery rate under dependence using the bootstrap and subsampling (2008)
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