CVCRAND: Stata module for efficient design and analysis of Cluster Randomized Trials

John A. Gallis (), Fan Li (), Hengshi Yu () and Elizabeth L. Turner ()
Additional contact information
John A. Gallis: Duke University
Fan Li: Duke University
Hengshi Yu: University of Michigan, Ann Arbor
Elizabeth L. Turner: Duke University

Statistical Software Components from Boston College Department of Economics

Abstract: Cluster randomized trials (CRTs), where clusters (for example, schools or clinics) are randomized but measurements are taken on individuals, are commonly used to evaluate interventions in public health and social science. Because CRTs typically involve only a few clusters, simple randomization frequently leads to baseline imbalance of cluster characteristics across treatment arms, threatening the internal validity of the trial. In CRTs with a small number of clusters, classic approaches to balancing baseline characteristics—such as matching and stratification—have several drawbacks, especially when the number of baseline characteristics the researcher desires to balance is large. An alternative approach is constrained randomization, whereby an allocation scheme is randomly selected from a subset of all possible allocation schemes based on the value of a balancing criterion. Subsequently, an adjusted clustered permutation test can be used in the analysis, which provides increased efficiency under constrained randomization compared with simple randomization. The program cvcrand facilitates the application of constrained randomization, and the program cptest allows the user to perform a clustered permutation test to analyze their cluster randomized trial.

Language: Stata
Requires: Stata version 14
Keywords: clinical trials; cluster trials; randomized trials (search for similar items in EconPapers)
Date: 2017-07-22, Revised 2020-03-27
Note: This module should be installed from within Stata by typing "ssc install cvcrand". The module is made available under terms of the GPL v3 (https://www.gnu.org/licenses/gpl-3.0.txt). Windows users should not attempt to download these files with a web browser.
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Downloads: (external link)
http://fmwww.bc.edu/repec/bocode/c/cvcrand.ado program code (text/plain)
http://fmwww.bc.edu/repec/bocode/c/cvcrand.sthlp help file (text/plain)
http://fmwww.bc.edu/repec/bocode/c/cptest.ado program code (text/plain)
http://fmwww.bc.edu/repec/bocode/c/cptest.sthlp help file (text/plain)
http://fmwww.bc.edu/repec/bocode/d/Dickinson_Data.dta sample data file (application/x-stata)
http://fmwww.bc.edu/repec/bocode/d/Dickinson_DataF ... e/_/corr_outcome.dta sample data file (application/x-stata)
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