FRAGILITY: Stata module to compute the fragility index and quotient

Ariel Linden

Statistical Software Components from Boston College Department of Economics

Abstract: fragility computes both the fragility index as described in Walsh et al. (2014) and the fragility quotient as proposed by Ahmed et al. (2016). The fragility index represents the absolute number of additional events (primary endpoints) required to obtain a P-value greater than or equal to a predetermined statistical significance threshold (typically set to 0.05). The fragility index is computed by adding an event to the group with the smaller number of events (and subtracting a non-event from the same group to keep the total number of patients constant) and recomputing the two-sided significance test (either Fisher's exact test or Pearson's chi-squared test). Events are iteratively added until the first time the computed P-value becomes equal to or greater than the desired level(). The fragility quotient is a relative measure of fragility which simply divides the absolute fragility index by the total sample size (Ahmed et al. 2016).

Language: Stata
Requires: Stata version 11
Keywords: fragility; replication crisis; randomized controlled trials; research methodology; statistical significance (search for similar items in EconPapers)
Date: 2019-11-08
Note: This module should be installed from within Stata by typing "ssc install fragility". The module is made available under terms of the GPL v3 (https://www.gnu.org/licenses/gpl-3.0.txt). Windows users should not attempt to download these files with a web browser.
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http://fmwww.bc.edu/repec/bocode/f/fragility.ado program code (text/plain)
http://fmwww.bc.edu/repec/bocode/f/fragility.sthlp help file (text/plain)

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