Overview of Progress in Chronic Graft-Versus-Host Disease

Nahla AM Hamed
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Nahla AM Hamed: Department of Hematology, Alexandria University, Egypt

Cancer Therapy & Oncology International Journal, 2018, vol. 9, issue 2, 57-60

Abstract: cGVHD is now known to be a more complex immune reaction. Thymic damage and aberrant antigen presentation leads to aberrant T- and B-cell reaction characterized by Th17/Tc17 differentiation, macrophage sequestration in tissue, alloantibody formation and TGFï ¢-dependent fibrosis. Inadequate peripheral tolerance resulting from Treg dysfunction or reduced numbers and reduced ratios of Tregs to T effector cells also play a role.

Keywords: juniper publishers:oncology journals; oncology research journals; oncology journal articles; oncology and cancer case reports; oncology journal of clinical and experimental cancer research; open access; open access journals; Oncology International Journal; juniper publishers reivew (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jctoij:v:9:y:2018:i:2:p:57-60

DOI: 10.19080/CTOIJ.2018.09.555760

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