Antidiabetic and Antihyperlipidemic Effects of Aqueous Extract of Carica papaya Leaf on the Experimental Model against Single Alloxan Toxicity

Ukpabi C.F., Chukwu M.n, J.N. Onyemaechi, Ibe P and Onuh E.F.

World Scientific Research, 2019, vol. 6, issue 1, 14-18

Abstract: Antidiabetic and antihyperlipidemic effects of aqueous extract of Carica papaya leaf on the toxicity were investigated. A total of thirty rats were divided into six groups of 5 rats: Group A: Normal control, Group B: Negative control, Group C: Positive control I, Group D: Positive control II, Group E: Test control I, Group F: Test control II. Diabetes was induced with a single dose of alloxan (120mg/kg) body weight and serum glucose was taken 72hrs after induction to confirm diabetes. The oral administration for hyperglycemia and hyperlipidemia started on the 4th and 8th day of the experiment respectively. The result showed that Carica papaya leaf extract significantly and progressively lowered the glucose level, TG, TC and LDL dose dependently while significantly causing a dose-related elevation in HDL concentration when compared to the untreated control and positive control groups (I & II) treated rats. Phytochemical analysis revealed the presence of alkaloids, flavonoids, saponins and tannins. The aqueous extract of this plant can be used to brew a tonic that will allay the metabolic disruption produced by diabetes.

Keywords: Carica papaya; Phytochemicals; Antidiabetic; hyperlipidemia activities; Lipoproteins; hyperglycermia (search for similar items in EconPapers)
Date: 2019
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