Optimal sampling times in population pharmacokinetic studies

Jonathan R. Stroud, Peter Müller and Gary L. Rosner

Journal of the Royal Statistical Society Series C, 2001, vol. 50, issue 3, 345-359

Abstract: We propose a simulation‐based approach to decision theoretic Bayesian optimal design. The underlying probability model is a population pharmacokinetic model which allows for correlated responses (drug concentrations) and patient‐to‐patient heterogeneity. We consider the problem of choosing sampling times for the anticancer agent paclitaxel, using criteria related to the total area under the curve, the time above a critical threshold and the sampling cost.

Date: 2001
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Persistent link: https://EconPapers.repec.org/RePEc:bla:jorssc:v:50:y:2001:i:3:p:345-359

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