Comparative study for optimal control nonlinear variable-order fractional tumor model

N.H. Sweilam, S.M. AL-Mekhlafi, A.S. Alshomrani and D. Baleanu

Chaos, Solitons & Fractals, 2020, vol. 136, issue C

Abstract: This article presents a variable order nonlinear mathematical model and its optimal control for a Tumor under immune suppression. The formulation generalizes the one proposed by Kim et. al. consisting of eleven integer order differential equations. The new approach adopts a variable-order fractional model with the derivatives defined in the Caputo sense. Two control variables, one for immunotherapy and one for Chemotherapy, are proposed to eliminate or reduce the Tumor cells. A simple numerical technique called the nonstandard generalized Euler method is developed to solve the proposed optimal control problem. Moreover, the stability analysis and the truncation error are studied. Numerical simulations and comparative studies are implemented. Our findings disclose that the proposed scheme used here has two main advantages: it is faster than the generalized Euler scheme and it can reduce the number of Tumor cells in a proper process better than the second scheme.

Keywords: Mathematical Tumor models; Immunotherapy; Chemotherapy; Variable-order fractional differential equations; Generalized Euler method; Nonstandard generalized Euler method (search for similar items in EconPapers)
Date: 2020
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Citations: View citations in EconPapers (4)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:chsofr:v:136:y:2020:i:c:s0960077920302113

DOI: 10.1016/j.chaos.2020.109810

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