Mathematical modeling, analysis and numerical simulation of HIV: The influence of stochastic environmental fluctuations on dynamics

Haokun Qi and Xinzhu Meng

Mathematics and Computers in Simulation (MATCOM), 2021, vol. 187, issue C, 700-719

Abstract: In this paper, we explore the effect of the stochastic environmental fluctuations on the dynamics of an HIV system with both virus-to-cell and cell-to-cell transmissions, intracellular delay, and humoral immunity. First, the existence and uniqueness of the global positive solution and the stochastically ultimate boundedness of the stochastic HIV system are discussed. Then, by constructing a series of suitable Lyapunov functions and using some differential inequality techniques, the long-time asymptotic properties of the stochastic delayed system are investigated. These properties reveal that the solution of the stochastic system oscillates around the equilibrium points of the deterministic system when the intensity of environmental perturbations is appropriate. In addition, the sufficient condition for persistence in mean and extinction of the stochastic system are established under the suitable condition. At last, numerous numerical simulations show that the HIV will disappear if the intensity of environmental fluctuations is sufficiently large. This means that appropriate stochastic environmental fluctuations can effectively suppress the outbreak of HIV.

Keywords: Stochastic environmental fluctuations; HIV system; Asymptotic properties; Lyapunov functions; Numerical simulation (search for similar items in EconPapers)
Date: 2021
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Citations: View citations in EconPapers (6)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:matcom:v:187:y:2021:i:c:p:700-719

DOI: 10.1016/j.matcom.2021.03.027

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