Understanding conserved amino acids in proteins

Nikolay V. Dokholyan, Leonid A. Mirny and Eugene I. Shakhnovich

Physica A: Statistical Mechanics and its Applications, 2002, vol. 314, issue 1, 600-606

Abstract: It has been conjectured that evolution exerted pressure to preserve amino acids bearing thermodynamic, kinetic, and functional roles. In this letter we show that the physical requirement to maintain protein stability gives rise to a sequence conservatism pattern that is in remarkable agreement with that found in natural proteins. Based on the physical properties of amino acids, we propose a model of evolution that explains conserved amino acids across protein families sharing the same fold.

Keywords: Protein evolution; Conserved amino acids; Model (search for similar items in EconPapers)
Date: 2002
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:314:y:2002:i:1:p:600-606

DOI: 10.1016/S0378-4371(02)01079-8

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