Effects of extracellular electric fields on electrical activities of two-compartment autaptic-neurons

Shanshan Li, Guoshan Zhang, Jiang Wang and Guosheng Yi

Physica A: Statistical Mechanics and its Applications, 2019, vol. 534, issue C

Abstract: In our work, we follow a modeling approach to investigate how extracellular electric fields affect the dynamics of two-compartment autaptic-neurons with morphological structures and how those effects translate into changes in electrical activities. Inter-spikes intervals bifurcation diagrams, frequency–input curves as well as phase-locking ratios are used to describe neural firing patterns, input sensitivities as well as mode-locking states. Modulated by extracellular electric fields, the autaptic-neurons exhibit subthreshold oscillation, tonic spiking, bursting and chaotic firing patterns. The input sensitivities and the mode-locking states are enhanced or suppressed depending on the parameters of extracellular electrical fields. Compared with autaptic-neurons with symmetrical structures, the autaptic-neuron with nonsymmetrical morphology have higher input sensitivities to extracellular electric fields, which suggest that neural geometric features play a crucial role in electric field effects on behaviors of neuron. Those results in our works provide a systematic understanding of effects of extracellular electric fields on the electrical activities of autaptic-neurons, which are further steps towards improving the design of electromagnetic brain stimulations.

Keywords: Autapses; Extracellular electrical fields; Interspikes intervals; Frequency–input curves; Firing patterns; Input sensitivities; Mode-locking states (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:eee:phsmap:v:534:y:2019:i:c:s0378437119313457

DOI: 10.1016/j.physa.2019.122331

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