 Dynamic lot sizing in biopharmaceutical manufacturingFlorian Sahling and Gerd J. Hahn International Journal of Production Economics, 2019, vol. 207, issue C, 96-106 Abstract: Biopharmaceutical products involve high margins but are subject to quality controls during production and to limited product shelf life. Consequently, production planning becomes a challenging task: both inventory and obsolescence costs must be reduced while finding lot sizes that ensure cost-efficient operations. In this paper, we consider operational lot sizing for a multi-level biopharmaceutical manufacturing process that is organized as a flexible flow shop, i.e., parallel and non-identical resources at several production levels. The manufacturing process involves both batch and serial production stages. The problem at hand has two industry-specific requirements: extensive quality checks per lot produced and a restricted shelf life for products. We formulate a mathematical model of this multi-level capacitated lot sizing problem and apply a Fix-and-Optimize heuristic to find high-quality solutions in a reasonable time frame. Modeling challenges and numerical results are provided using a real-life case example from the biopharmaceutical industry. Keywords: Biopharmaceutical industry; Multi-level lot sizing; Quality control; Shelf life; Fix-and-Optimize heuristic (search for similar items in EconPapers) Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:eee:proeco:v:207:y:2019:i:c:p:96-106 DOI: 10.1016/j.ijpe.2018.11.006 Access Statistics for this article International Journal of Production Economics is currently edited by Stefan Minner More articles in International Journal of Production Economics from Elsevier |
Is your work missing from RePEc? Here is how to contribute.
Questions or problems? Check the EconPapers FAQ or send mail to .
EconPapers is hosted by the
School of Business at Örebro University.