An adaptive design for clinical trials with non-dichotomous response and prognostic factors

José A. Moler, Fernando Plo and Miguel San Miguel

Statistics & Probability Letters, 2006, vol. 76, issue 17, 1940-1946

Abstract: We present an adaptive design for multi-arm clinical trials with bounded response and prognostic factors. The allocation is ruled by an urn model that fits a Robbins-Monro scheme. We obtain asymptotic properties for the performance and allocation of treatments.

Keywords: Adaptive; designs; Urn; models; Robbins-Monro; Algorithm; Asymptotic; limits (search for similar items in EconPapers)
Date: 2006
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