A Bartlett type correction for Wald test in Cox regression model

Xiao Li, Yaohua Wu and Dongsheng Tu

Statistics & Probability Letters, 2008, vol. 78, issue 16, 2614-2622

Abstract: In clinical trials with time to an event endpoint, the Wald test in a Cox regression model may be used to assess the difference between two treatments. In this paper, a Bartlett type correction to the Wald test is derived and applied to the analysis of data from a clinical trial on actuate myelogenous leukemia (AML). Monte Carlo simulations are also performed to assess the actual type I error and power of the proposed Bartlett corrected test.

Date: 2008
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