Linear increment in efficiency with the inclusion of surrogate endpoint

Buddhananda Banerjee and Atanu Biswas

Statistics & Probability Letters, 2015, vol. 96, issue C, 102-108

Abstract: In a two-sample clinical trial, a fixed proportion of true-and-surrogate and the remaining only-surrogate responses are observed. We quantify the increase in efficiency to compare the treatments as a linear function of the proportion of available true responses.

Keywords: Surrogate responses; Odds ratio; Risk ratio; Treatment difference (search for similar items in EconPapers)
Date: 2015
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DOI: 10.1016/j.spl.2014.09.015

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