The third moments of the site frequency spectrum

A. Klassmann and L. Ferretti

Theoretical Population Biology, 2018, vol. 120, issue C, 16-28

Abstract: The analysis of patterns of segregating (i.e. polymorphic) sites in aligned sequences is routine in population genetics. Quantities of interest include the total number of segregating sites and the number of sites with mutations of different frequencies, the so-called site frequency spectrum. For neutrally evolving sequences, some classical results are available, including the expected value and variance of the spectrum in the Kingman coalescent model without recombination as calculated by Fu (1995).

Keywords: Single nucleotide polymorphisms; Infinite-sites model; Site frequency spectrum; Coalescent approximation; Nested mutations; Skewness (search for similar items in EconPapers)
Date: 2018
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Citations: View citations in EconPapers (2)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:thpobi:v:120:y:2018:i:c:p:16-28

DOI: 10.1016/j.tpb.2017.12.002

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