The structured coalescent in the context of gene copy number variation

Moritz Otto and Thomas Wiehe

Theoretical Population Biology, 2023, vol. 154, issue C, 67-78

Abstract: The Structured Coalescent was introduced to describe the coalescent process in spatially subdivided populations with migration. Here, we re-interpret migration routes of individuals in the original model as “migration routes†of single genes in tandemly arranged gene arrays. A gene copy may change its position within the array via unequal recombination. Hence, in a coalescent framework, two copies sampled from two chromosomes may coalesce only if they are at exactly homologous positions. Otherwise, one or multiple recombination events have to occur before they can coalesce, thereby increasing mean coalescence time and expected genetic diversity among the copies in a gene array.

Keywords: Gene duplication; Structured coalescent; Gamma distribution; Site frequency spectrum; Unequal recombination (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:eee:thpobi:v:154:y:2023:i:c:p:67-78

DOI: 10.1016/j.tpb.2023.08.001

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