Efficient maximum likelihood pedigree reconstruction

Robert G. Cowell

Theoretical Population Biology, 2009, vol. 76, issue 4, 285-291

Abstract: A simple and efficient algorithm is presented for finding a maximum likelihood pedigree using microsatellite (STR) genotype information on a complete sample of related individuals. The computational complexity of the algorithm is at worst (O(n32n)), where n is the number of individuals. Thus it is possible to exhaustively search the space of all pedigrees of up to thirty individuals for one that maximizes the likelihood. A priori age and sex information can be used if available, but is not essential. The algorithm is applied in a simulation study, and to some real data on humans.

Keywords: Pedigree reconstruction; Bayesian network; Maximum likelihood (search for similar items in EconPapers)
Date: 2009
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Citations: View citations in EconPapers (7)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:thpobi:v:76:y:2009:i:4:p:285-291

DOI: 10.1016/j.tpb.2009.09.002

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